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EROP-Moscow Peptide Page
Record E00002
EROP-Moscow release of 29-Jun-2020

Terms
oligopeptide name Oxytocin
synonyms Ocytocin
EROP accession E00002
entered in EROP-Moscow in 11.11.1987
last modified in 23.06.2009
UniProt accession P01175 

First source of oligopeptide
karyote eukaryote (Eukaryota)
empire/kingdom animal (Animalia)
phylum vertebrate (Chordata)
all classes mammalian (Mammalia), fish (Pisces)
first organism bovine
first taxon Bos taurus
tissue/organ/cell/secreted pituitary gland, brain, hypothalami
content -
all sources bovine (Bos taurus)

First amino acid sequence determination
structural family OT 
amino acid number 9.0
side + terminal radical number 11
sequence +CYIQNCPLGz
S-S bond(s) 1-6
PubMed
Part of Oxytocin-neurophysin I precursor [20-28] of 125
post translation modification(s) -
PubMed
molecular mass (experimental) -
molecular mass (calculated) 1007,2
pI (experimental) -
pI (calculated) 10,4
positive charges 1
negative charges -
net charge +1
spatial structure
synthesis
first amino acid sequence reference Author(s): Tuppy H.
Title: The amino acid sequence in oxytocin.
Journal/Book: Biochimica et Biophysica Acta, 11, #3, 449-50.
Year: 1953
Countries: Ost USA
PubMed

First nucleotide sequence determination
sequence ---
first nucleotide sequence reference Author(s): Ruppert S,Scherer G,Schutz G.
Title: Recent gene conversion involving bovine vasopressin and oxytocin precursor genes suggested by nucleotide sequence.
Journal/Book: Nature, 308, #5959, 554-7.
Year: 1984
Countries: ---
PubMed 6709064

First function determination
function class hormone
function causes contraction of the smooth muscle of the uterus and the mammary gland
first function reference ---

Comments * the second publication: du Vineaud V, Ressler C, Trippett S. The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin. Journal of Biological Chemistry, 205, #2, 949-57, 1953.

UniProt PIR PDB PubMed